Wirkstoffdesign Entwurf Und Wirkung Von Arzneistoffen Book PDF, EPUB Download & Read Online Free

Wirkstoffdesign
Author: Gerhard Klebe
Publisher: Springer-Verlag
ISBN: 3827422132
Pages: 637
Year: 2009-06-29
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Dieses für den deutschen Raum einzigartige Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Die zweite Auflage ist komplett überarbeitet. Zahlreiche aktuelle Entwicklungen vor allem im methodischen Bereich sind zum Teil in neuen Kapiteln aufgegriffen, viele Fallbeispiele machen die Theorien und Verfahren anschaulich und nachvollziehbar. Der Bogen spannt sich von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsmethoden, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design. Insgesamt legt das Buch besonderen Wert auf die räumliche Struktur der interagierenden Moleküle und erklärt, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Die beiliegende DVD mit interaktiven Molekülmodellen dient dem Ziel, dem Lernenden einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen zu geben.
Interaktive Tafeln im naturwissenschaftlichen Unterricht
Author: Bernhard F. Sieve
Publisher: Springer-Verlag
ISBN: 3658099461
Pages: 341
Year: 2015-05-29
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Bernhard F. Sieve untersucht die Nutzung Interaktiver Whiteboards (IWB) im naturwissenschaftlichen Unterricht. Er erfasst zunächst aus Lehrerperspektive vorherrschende Einstellungen, Kenntnisse und Bedürfnisse sowie aktuelle Nutzungsweisen von IWB. Auf dieser Grundlage entwickelt er eine spezifische Fortbildung für Chemielehrkräfte. Inhaltliche Schwerpunkte der Lehrerfortbildung sind die Potenziale digitaler Tafeln für die Planung, Durchführung und Auswertung von Experimenten sowie beim Umgang mit Visualisierungen von Teilchendarstellungen. Die Wirksamkeitsprüfung der Fortbildung zeigt eine deutliche Kompetenzentwicklung hinsichtlich der Einstellungsmuster, der Kooperationsbereitschaft und vor allem der Einsatzweisen digitaler Tafeln im Chemieunterricht.
Charles Darwin
Author: Paul Wrede, Saskia Wrede
Publisher: John Wiley & Sons
ISBN: 3527332561
Pages: 599
Year: 2013-01-29
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Das grundlegende Werk von Darwin On the Origin of Species liegt hier in der originalen Übersetzung durch Julius Victor Carus vor, erweitert durch zahlreiche Erläuterungen, aussagekräftige Abbildungen sowie wichtige historische Bezüge. Die Entstehung der Arten von Darwin ist für die heutige Leserschaft häufig schwierig zu verstehen. Eine hilfreiche Unterstützung erfolgt durch die farbliche Hervorhebung entscheidender Textstellen und viele fachliche Erklärungen. Darwins Analysen und Bewertungen aus den Gebieten der Botanik, Zoologie, Verhaltenslehre, Paläontologie und Entwicklungsbiologie werden in acht Beiträgen namhafter Fachwissenschaftler im Licht der gegenwärtigen Forschung beleuchtet und so wird erst die ungeheure Bedeutung und Weitsicht seines Werkes offensichtlich. Endlich liegen jetzt die Übersetzungen der beiden ebenso bahnbrechenden Aufsätze von Alfred Russel Wallace vor: der Sarawak- und Ternate-Essay. Wallace war neben Darwin der bedeutendste Evolutionsforscher seiner Zeit. Seine Arbeiten zur Evolutionsbiologie, die im Angelsächsischen hoch geschätzt sind, können als durchaus gleichrangig zu Darwins berühmtester Schrift angesehen werden. Ulrich Kutschera eröffnet das Buch mit einem Geleitwort und Reinhold Leinfelder schließt es mit einem Ausblick zur Bedeutung der Evolutionstheorie für die Zukunft des Menschen ab. Das Buch ist daher nicht nur eine unverzichtbare Lernhilfe für Schüler und Studenten, die sich mit der Evolutionsbiologie beschäftigen, sondern zusätzlich auch eine spannende weiterführende Lektüre für alle Leser mit Interesse an Wissenschaftsgeschichte.
Bioactive Compounds from Natural Sources, Second Edition
Author: Corrado Tringali
Publisher: CRC Press
ISBN: 1439822298
Pages: 648
Year: 2011-09-27
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The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.
Phenomenology: East and West
Author: Frank M. Kirkland, D P Chattopadhyaya
Publisher: Springer Science & Business Media
ISBN: 9401116121
Pages: 319
Year: 2012-12-06
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To know the work of Jitendra Nath Mohanty even slightly is to commence to appreciate it immensely. Lucidity and sagacity have been its armor; originality and ingenuity have been its strength. And wearing the former and wielding the latter have become so persistent a mark of his work as to suggest that their appeal for Mohanty lies altogether more in the refmed reaches of philosophical craftsmanship than on the coarse ground of intellectual partisanship. The multifaceted character of his work in phenomenology and Indian philosophy has never left us palled by its significance and, as a consequence, has always left us conceding its command on our philosophical discourse. It has fulfilled the most welcomed promise of striking the chords of both imagination and reason by exposing Husserlian phenomenology to the concerns of both the so-called "analytical" and "continental" traditions and by exposing the philosophical tradition of Indian thought to the intricacies of Husserl. Although charting and periodizing the body ofMohanty' s work in phenomeno logy may be the function of a memory inconspicuous for originality and liveli ness, they nonetheless offer a precis conspicuous for the variety of topics that Mohanty has both engaged and enriched. Mohanty's career in phenomenology can be characterized by three phases, each concentrating on different themes, but with the latter two also epitomizing a more incisive and deeper discussion of the issues raised in the first.
Signposts to Chiral Drugs
Author: Vitomir Sunjic, Michael Parnham
Publisher: Springer Science & Business Media
ISBN: 3034801254
Pages: 232
Year: 2011-05-10
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Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry. The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book. Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.
Structure-based Drug Design
Author: John E. Ladbury, Patrick R. Connelly
Publisher: R G Landes Company
ISBN: 3540632506
Pages: 187
Year: 1997-01-01
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This book connects two subjects: "drug design" - a biological science - and "thermodynamics" - a physical science. Armed with the knowledge of the three-dimensional structure of a potential binding site of a molecule, the method of structure-based design provides a rapid, rational route to a ligand molecule. Recent developments in the determination of structure and the measurement of thermodynamic parameters of binding have resulted in drawing theoretical and experimental data together to improve our ability to model these interactions de novo. This book presents the state of the art and outlines future developments in the field of structure-based ligand design.
Safety Evaluation of Pharmaceuticals and Medical Devices
Author: Shayne C. Gad
Publisher: Springer Science & Business Media
ISBN: 1441974490
Pages: 126
Year: 2010-10-26
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The inspiration for this text was the 1988 volume by Alder and Zbinden, written before the ICH harmonization process for drug safety evaluation (or its ISO analog for device biocompatibility evaluation) had been initiated or come to force. Since then, much has changed in both the world and practice of medicine and the regulation of drugs. The intent of this volume is to provide similar guidance as to what nonclinical safety assessment tests need to be performed to move a drug into man, through development and to market approved (this intent was subsequently extended to cover the closely related medical device biotechnology, and combination product fields) in a concise, abbreviated manner for all the major world market countries.
Biotechnology
Author: David P. Clark, Nanette J. Pazdernik
Publisher: Newnes
ISBN: 0123850169
Pages: 850
Year: 2015-05-16
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Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future. Up-to-date text focuses on modern biotechnology with a molecular foundation Includes clear, color illustrations of key topics and concept Features clearly written without overly technical jargon or complicated examples Provides a comprehensive supplements package with an easy-to-use study guide, full primary research articles that demonstrate how research is conducted, and instructor-only resources
Chemical Evolution and the Origin of Life
Author: Horst Rauchfuss
Publisher: Springer Science & Business Media
ISBN: 3540788239
Pages: 339
Year: 2008-10-15
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How did life begin on the early Earth? We know that life today is driven by the universal laws of chemistry and physics. By applying these laws over the past ?fty years, en- mous progress has been made in understanding the molecular mechanisms that are the foundations of the living state. For instance, just a decade ago, the ?rst human genome was published, all three billion base pairs. Using X-ray diffraction data from crystals, we can see how an enzyme molecule or a photosynthetic reaction center steps through its catalytic function. We can even visualize a ribosome, central to all life, translate - netic information into a protein. And we are just beginning to understand how molecular interactions regulate thousands of simultaneous reactions that continuously occur even in the simplest forms of life. New words have appeared that give a sense of this wealth of knowledge: The genome, the proteome, the metabolome, the interactome. But we can’t be too smug. We must avoid the mistake of the physicist who, as the twentieth century began, stated con?dently that we knew all there was to know about physics, that science just needed to clean up a few dusty corners. Then came relativity, quantum theory, the Big Bang, and now dark matter, dark energy and string theory. Similarly in the life sciences, the more we learn, the better we understand how little we really know. There remains a vast landscape to explore, with great questions remaining.
A guide to the chemical basis of drug design
Author: Alfred Burger
Publisher: John Wiley & Sons Inc
ISBN:
Pages: 300
Year: 1983
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The Bright Blue Sky
Author: Max Hennessy
Publisher: House of Stratus
ISBN: 0755128028
Pages: 286
Year: 2012-05-19
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The reckless days of early aviation are brought to life in a tale of daring, dashing young pilots waging war, and of the raging struggle between the hearts of two brave men for the heart of a beautiful woman.
Renal Cell Carcinoma
Author: Ronald Bukowski, Robert A. Figlin, Robert Motzer
Publisher: Springer
ISBN: 149391622X
Pages: 613
Year: 2014-11-27
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​​ ​The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.​
Wired For God?
Author: Charles Foster
Publisher: Hodder
ISBN: 1444722050
Pages: 352
Year: 2011-12-08
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Human religious experiences are remarkably uniform; many can be pharmacologically induced. Recent research into the neurology of religious experience has shown that, when worshipping or praying, a certain part of the brain, apparently dormant during other activities, becomes active. What does all this mean for those of faith and those with none? In this fascinating book barrister Charles Foster takes a survey of the evidence - from shamans to medieval mystics, to out-of-body experiences and epilepsy, via Jerusalem and middle-class Christianity - and assesses its significance. Written in short, accessible chapters, this is a fascinating tour of religious and mystical experiences and their relation to human physiology.
Protein-Ligand Interactions
Author: Holger Gohlke
Publisher: John Wiley & Sons
ISBN: 3527329668
Pages: 339
Year: 2012-05-21
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Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental methods (calorimetry, surface plasmon resonance, NMR) used in generating interaction data. The second half of the book is devoted to insilico methods of modeling and predicting molecular recognition and binding, ranging from first principles-based to approximate ones. Here, as elsewhere in the book, emphasis is placed on novel approaches and recent improvements to established methods. The final part looks at unresolved challenges, and the strategies to address them. With the content relevant for all drug classes and therapeutic fields, this is an inspiring and often-consulted guide to the complexity of protein-ligand interaction modeling and analysis for both novices and experts.